Functional characterization of two human MutY homolog (hMYH) missense mutations (R227W and V232F) that lie within the putative hMSH6 binding domain and are associated with hMYH polyposis

The base excision repair DNA glycosylase MutY homolog (MYH) is responsible for removing adenines misincorporated into DNA opposite guanine or 7,8-dihydro-8-oxo-guanine (8-oxoG), thereby preventing G:C to T:A mutations. Biallelic germline mutations in the human MYH gene predispose individuals to mult...

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Detalles Bibliográficos
Autores principales: Bai, Haibo, Jones, Siân, Guan, Xin, Wilson, Teresa M., Sampson, Julian R., Cheadle, Jeremy P., Lu, A-Lien
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC548354/
https://www.ncbi.nlm.nih.gov/pubmed/15673720
http://dx.doi.org/10.1093/nar/gki209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC548354/
https://www.ncbi.nlm.nih.gov/pubmed/15673720
http://dx.doi.org/10.1093/nar/gki209

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