A functional analysis of the DNA glycosylase activity of mouse MUTYH protein excising 2-hydroxyadenine opposite guanine in DNA

2-Hydroxy-2-deoxyadenosine triphosphate (2-OH-dATP), generated by the oxidation of dATP, can be misincorporated by DNA polymerases opposite guanine in template DNA during DNA replication, thus causing spontaneous mutagenesis. We demonstrated that mouse MUTYH (mMUTYH) has a DNA glycosylase activity e...

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Detalles Bibliográficos
Autores principales: Ushijima, Yasuhiro, Tominaga, Yohei, Miura, Tomofumi, Tsuchimoto, Daisuke, Sakumi, Kunihiko, Nakabeppu, Yusaku
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC548358/
https://www.ncbi.nlm.nih.gov/pubmed/15681617
http://dx.doi.org/10.1093/nar/gki214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC548358/
https://www.ncbi.nlm.nih.gov/pubmed/15681617
http://dx.doi.org/10.1093/nar/gki214

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