Cargando…

A hepatitis C virus (HCV) internal ribosome entry site (IRES) domain III–IV-targeted aptamer inhibits translation by binding to an apical loop of domain IIId

The hepatitis C virus (HCV) has a positive single-stranded RNA genome, and translation starts within the internal ribosome entry site (IRES) in a cap-independent manner. The IRES is well conserved among HCV subtypes and has a unique structure consisting of four domains. We used an in vitro selection...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kikuchi, Kunio, Umehara, Takuya, Fukuda, Kotaro, Kuno, Atsushi, Hasegawa, Tsunemi, Nishikawa, Satoshi
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC548359/ https://www.ncbi.nlm.nih.gov/pubmed/15681618 http://dx.doi.org/10.1093/nar/gki215

Ejemplares similares

Positioning of subdomain IIId and apical loop of domain II of the hepatitis C IRES on the human 40S ribosome
por: Babaylova, Elena, et al.
Publicado: (2009)

LOOP IIId of the HCV IRES is essential for the structural rearrangement of the 40S-HCV IRES complex
por: Angulo, Jenniffer, et al.
Publicado: (2016)

Distinct roles for the IIId2 sub-domain in pestivirus and picornavirus internal ribosome entry sites
por: Willcocks, Margaret M., et al.
Publicado: (2017)

Structure and function of HCV IRES domains
por: Lukavsky, Peter J.
Publicado: (2009)

The beta hairpin structure within ribosomal protein S5 mediates interplay between domains II and IV and regulates HCV IRES function
por: Bhat, Prasanna, et al.
Publicado: (2015)

Comparison between the HCV IRES domain IV RNA structure and the Iron Responsive Element
por: Tumban, Ebenezer, et al.
Publicado: (2009)

HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation
por: Filbin, Megan E., et al.
Publicado: (2012)

Ribosome-dependent conformational flexibility changes and RNA dynamics of IRES domains revealed by differential SHAPE
por: Lozano, Gloria, et al.
Publicado: (2018)

Use and comparison of different internal ribosomal entry sites (IRES) in tricistronic retroviral vectors
por: Douin, Victorine, et al.
Publicado: (2004)

IRESPred: Web Server for Prediction of Cellular and Viral Internal Ribosome Entry Site (IRES)
por: Kolekar, Pandurang, et al.
Publicado: (2016)

Dissemination of Internal Ribosomal Entry Sites (IRES) Between Viruses by Horizontal Gene Transfer
por: Arhab, Yani, et al.
Publicado: (2020)

Three Cases of Hemiconvulsion-Hemiplegia-Epilepsy Syndrome With Focal Cortical Dysplasia Type IIId
por: Itamura, Shinji, et al.
Publicado: (2019)

Structural characterization of ribosome recruitment and translocation by type IV IRES
por: Murray, Jason, et al.
Publicado: (2016)

Conformational inhibition of the HCV IRES RNA
por: Parsons, Jerod, et al.
Publicado: (2009)

HCV IRES interacts with the 18S rRNA to activate the 40S ribosome for subsequent steps of translation initiation
por: Malygin, Alexey A., et al.
Publicado: (2013)

HCV IRES-Mediated Core Expression in Zebrafish
por: Zhao, Ye, et al.
Publicado: (2013)

An Internal Ribosome Entry Site (IRES) Mutant Library for Tuning Expression Level of Multiple Genes in Mammalian Cells
por: Koh, Esther Y. C., et al.
Publicado: (2013)

Survival of patients with stage IIIC and IIID melanomas with nodal metastases in the light of new therapies
por: Ziętek, Marcin, et al.
Publicado: (2022)

Internal Ribosome Entry Site (IRES)-Mediated Translation and Its Potential for Novel mRNA-Based Therapy Development
por: Marques, Rita, et al.
Publicado: (2022)

Candidate RNA structures for domain 3 of the foot-and-mouth-disease virus internal ribosome entry site
por: Jung, Segun, et al.
Publicado: (2013)

Insect Innate Immunity Database (IIID): An Annotation Tool for Identifying Immune Genes in Insect Genomes
por: Brucker, Robert M., et al.
Publicado: (2012)

The bHLH Subgroup IIId Factors Negatively Regulate Jasmonate-Mediated Plant Defense and Development
por: Song, Susheng, et al.
Publicado: (2013)

A Polarized Cell Model for Chikungunya Virus Infection: Entry and Egress of Virus Occurs at the Apical Domain of Polarized Cells
por: Lim, Pei Jin, et al.
Publicado: (2014)

Quasispecies Changes with Distinctive Point Mutations in the Hepatitis C Virus Internal Ribosome Entry Site (IRES) Derived from PBMCs and Plasma
por: Mercuri, Luca, et al.
Publicado: (2018)

Surgical outcome in neocortical resections of type IIId focal cortical dysplasia with accompanying medial temporal pathology()
por: Garganis, Kyriakos, et al.
Publicado: (2012)

La Autoantigen Induces Ribosome Binding Protein 1 (RRBP1) Expression through Internal Ribosome Entry Site (IRES)-Mediated Translation during Cellular Stress Condition
por: Gao, Wenqing, et al.
Publicado: (2016)

Activity of the human immunodeficiency virus type 1 cell cycle-dependent internal ribosomal entry site is modulated by IRES trans-acting factors
por: Vallejos, Maricarmen, et al.
Publicado: (2011)

Structural basis for the biological relevance of the invariant apical stem in IRES-mediated translation
por: Fernández, Noemí, et al.
Publicado: (2011)

Disruption of IRE1α through its kinase domain attenuates multiple myeloma
por: Harnoss, Jonathan M., et al.
Publicado: (2019)

Apical domain polarization localizes actin-myosin activity to drive ratchet-like apical constriction
por: Mason, Frank M., et al.
Publicado: (2013)

Receptor Complementation and Mutagenesis Reveal SR-BI as an Essential HCV Entry Factor and Functionally Imply Its Intra- and Extra-Cellular Domains
por: Dreux, Marlène, et al.
Publicado: (2009)

Understanding the potential of hepatitis C virus internal ribosome entry site domains to modulate translation initiation via their structure and function
por: Khawaja, Anas, et al.
Publicado: (2015)

A cluster of methylations in the domain IV of 25S rRNA is required for ribosome stability
por: Gigova, Andriana, et al.
Publicado: (2014)

Comparison of Internal Ribosome Entry Site (IRES) and Furin-2A (F2A) for Monoclonal Antibody Expression Level and Quality in CHO Cells
por: Ho, Steven C. L., et al.
Publicado: (2013)

Structural basis for the binding of IRES RNAs to the head of the ribosomal 40S subunit
por: Muhs, Margarita, et al.
Publicado: (2011)

Aminopeptidase N is directly sorted to the apical domain in MDCK cells
Publicado: (1990)

Suppression of amyloid fibrils using the GroEL apical domain
por: Ojha, Bimlesh, et al.
Publicado: (2016)

Hydroxylated sphingolipid biosynthesis regulates photoreceptor apical domain morphogenesis
por: Hebbar, Sarita, et al.
Publicado: (2020)

Targeting HCV Entry For Development of Therapeutics
por: Wong-Staal, Flossie, et al.
Publicado: (2010)

Lysosomotropic agents as HCV entry inhibitors
por: Ashfaq, Usman A, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_gqpq9u8stevb77k70lh478skfp