NMR structures of double loops of an RNA aptamer against mammalian initiation factor 4A

A high affinity RNA aptamer (APT58, 58 nt long) against mammalian initiation factor 4A (eIF4A) requires nearly its entire nucleotide sequence for efficient binding. Since splitting either APT58 or eIF4A into two domains diminishes the affinity for each other, it is suggested that multiple interactio...

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Detalles Bibliográficos
Autores principales: Sakamoto, Taiichi, Oguro, Akihiro, Kawai, Gota, Ohtsu, Takashi, Nakamura, Yoshikazu
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC548364/
https://www.ncbi.nlm.nih.gov/pubmed/15687383
http://dx.doi.org/10.1093/nar/gki222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC548364/
https://www.ncbi.nlm.nih.gov/pubmed/15687383
http://dx.doi.org/10.1093/nar/gki222

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