Repurposing Suzuki Coupling Reagents as a Directed Fragment Library Targeting Serine Hydrolases and Related Enzymes

[Image: see text] Serine hydrolases are susceptible to potent reversible inhibition by boronic acids. Large collections of chemically diverse boronic acid fragments are commercially available because of their utility in coupling chemistry. We repurposed the approximately 650 boronic acid reagents in...

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Detalles Bibliográficos
Autores principales: Lanier, Marion, Cole, Derek C., Istratiy, Yelena, Klein, Michael G., Schwartz, Phillip A., Tjhen, Richard, Jennings, Andy, Hixon, Mark S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483892/
https://www.ncbi.nlm.nih.gov/pubmed/28564542
http://dx.doi.org/10.1021/acs.jmedchem.6b01224

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483892/
https://www.ncbi.nlm.nih.gov/pubmed/28564542
http://dx.doi.org/10.1021/acs.jmedchem.6b01224

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