Repurposing Suzuki Coupling Reagents as a Directed Fragment Library Targeting Serine Hydrolases and Related Enzymes

[Image: see text] Serine hydrolases are susceptible to potent reversible inhibition by boronic acids. Large collections of chemically diverse boronic acid fragments are commercially available because of their utility in coupling chemistry. We repurposed the approximately 650 boronic acid reagents in...

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Autores principales: Lanier, Marion, Cole, Derek C., Istratiy, Yelena, Klein, Michael G., Schwartz, Phillip A., Tjhen, Richard, Jennings, Andy, Hixon, Mark S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483892/
https://www.ncbi.nlm.nih.gov/pubmed/28564542
http://dx.doi.org/10.1021/acs.jmedchem.6b01224
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author Lanier, Marion
Cole, Derek C.
Istratiy, Yelena
Klein, Michael G.
Schwartz, Phillip A.
Tjhen, Richard
Jennings, Andy
Hixon, Mark S.
author_facet Lanier, Marion
Cole, Derek C.
Istratiy, Yelena
Klein, Michael G.
Schwartz, Phillip A.
Tjhen, Richard
Jennings, Andy
Hixon, Mark S.
author_sort Lanier, Marion
collection PubMed
description [Image: see text] Serine hydrolases are susceptible to potent reversible inhibition by boronic acids. Large collections of chemically diverse boronic acid fragments are commercially available because of their utility in coupling chemistry. We repurposed the approximately 650 boronic acid reagents in our collection as a directed fragment library targeting serine hydrolases and related enzymes. Highly efficient hits (LE > 0.6) often result. The utility of the approach is illustrated with the results against autotaxin, a phospholipase implicated in cardiovascular disease.
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spelling pubmed-54838922017-06-27 Repurposing Suzuki Coupling Reagents as a Directed Fragment Library Targeting Serine Hydrolases and Related Enzymes Lanier, Marion Cole, Derek C. Istratiy, Yelena Klein, Michael G. Schwartz, Phillip A. Tjhen, Richard Jennings, Andy Hixon, Mark S. J Med Chem [Image: see text] Serine hydrolases are susceptible to potent reversible inhibition by boronic acids. Large collections of chemically diverse boronic acid fragments are commercially available because of their utility in coupling chemistry. We repurposed the approximately 650 boronic acid reagents in our collection as a directed fragment library targeting serine hydrolases and related enzymes. Highly efficient hits (LE > 0.6) often result. The utility of the approach is illustrated with the results against autotaxin, a phospholipase implicated in cardiovascular disease. American Chemical Society 2017-05-31 2017-06-22 /pmc/articles/PMC5483892/ /pubmed/28564542 http://dx.doi.org/10.1021/acs.jmedchem.6b01224 Text en Copyright © 2017 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Lanier, Marion
Cole, Derek C.
Istratiy, Yelena
Klein, Michael G.
Schwartz, Phillip A.
Tjhen, Richard
Jennings, Andy
Hixon, Mark S.
Repurposing Suzuki Coupling Reagents as a Directed Fragment Library Targeting Serine Hydrolases and Related Enzymes
title Repurposing Suzuki Coupling Reagents as a Directed Fragment Library Targeting Serine Hydrolases and Related Enzymes
title_full Repurposing Suzuki Coupling Reagents as a Directed Fragment Library Targeting Serine Hydrolases and Related Enzymes
title_fullStr Repurposing Suzuki Coupling Reagents as a Directed Fragment Library Targeting Serine Hydrolases and Related Enzymes
title_full_unstemmed Repurposing Suzuki Coupling Reagents as a Directed Fragment Library Targeting Serine Hydrolases and Related Enzymes
title_short Repurposing Suzuki Coupling Reagents as a Directed Fragment Library Targeting Serine Hydrolases and Related Enzymes
title_sort repurposing suzuki coupling reagents as a directed fragment library targeting serine hydrolases and related enzymes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483892/
https://www.ncbi.nlm.nih.gov/pubmed/28564542
http://dx.doi.org/10.1021/acs.jmedchem.6b01224
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