Brucella Omp25 Upregulates miR-155, miR-21-5p, and miR-23b to Inhibit Interleukin-12 Production via Modulation of Programmed Death-1 Signaling in Human Monocyte/Macrophages

Brucella spp. infection results in compromised Type1 (Th1) cellular immune response. Several reports have described an immunomodulatory function for Brucella major outer membrane protein Omp25. However, the mechanism by which Omp25 modulates macrophage dysfunction has not been defined. Herein, we re...

Descripción completa

Detalles Bibliográficos
Autores principales: Cui, Beibei, Liu, Wenli, Wang, Xiaoya, Chen, Yu, Du, Qian, Zhao, Xiaomin, Zhang, Hai, Liu, Shan-Lu, Tong, Dewen, Huang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483987/
https://www.ncbi.nlm.nih.gov/pubmed/28694807
http://dx.doi.org/10.3389/fimmu.2017.00708

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483987/
https://www.ncbi.nlm.nih.gov/pubmed/28694807
http://dx.doi.org/10.3389/fimmu.2017.00708

Ejemplares similares