Cargando…

Identification of a Novel O-Conotoxin Reveals an Unusual and Potent Inhibitor of the Human α9α10 Nicotinic Acetylcholine Receptor

Conotoxins are a pool of disulfide-rich peptide neurotoxins produced by cone snails for predation and defense. They are a rich reservoir of novel ligands for ion channels, neurotransmitter receptors and transporters in the nervous system. In this study, we identified a novel conotoxin component, O-c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Shantong, Tae, Han-Shen, Xu, Shaoqiong, Shao, Xiaoxia, Adams, David J., Wang, Chunguang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484120/ https://www.ncbi.nlm.nih.gov/pubmed/28598389 http://dx.doi.org/10.3390/md15060170

Ejemplares similares

A Novel Lid-Covering Peptide Inhibitor of Nicotinic Acetylcholine Receptors Derived from αD-Conotoxin GeXXA
por: Yang, Longjin, et al.
Publicado: (2017)

Conotoxin αD-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors
por: Xu, Shaoqiong, et al.
Publicado: (2015)

Ribbon α-Conotoxin KTM Exhibits Potent Inhibition of Nicotinic Acetylcholine Receptors
por: Marquart, Leanna A., et al.
Publicado: (2019)

Conotoxin Interactions with α9α10-nAChRs: Is the α9α10-Nicotinic Acetylcholine Receptor an Important Therapeutic Target for Pain Management?
por: Mohammadi, Sarasa A., et al.
Publicado: (2015)

Mutagenesis of α-Conotoxins for Enhancing Activity and Selectivity for Nicotinic Acetylcholine Receptors
por: Turner, Matthew W., et al.
Publicado: (2019)

Orthosteric and/or Allosteric Binding of α-Conotoxins to Nicotinic Acetylcholine Receptors and Their Models
por: Kryukova, Elena V., et al.
Publicado: (2018)

The α9α10 Nicotinic Acetylcholine Receptor Antagonist αO-Conotoxin GeXIVA[1,2] Alleviates and Reverses Chemotherapy-Induced Neuropathic Pain
por: Wang, Huanbai, et al.
Publicado: (2019)

αO-Conotoxin GeXIVA Inhibits the Growth of Breast Cancer Cells via Interaction with α9 Nicotine Acetylcholine Receptors
por: Sun, Zhihua, et al.
Publicado: (2020)

A Novel Inhibitor of α9α10 Nicotinic Acetylcholine Receptors from Conus vexillum Delineates a New Conotoxin Superfamily
por: Luo, Sulan, et al.
Publicado: (2013)

Lyophilization Serves as an Effective Strategy for Drug Development of the α9α10 Nicotinic Acetylcholine Receptor Antagonist α-Conotoxin GeXIVA[1,2]
por: Li, Zhiguo, et al.
Publicado: (2021)

Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor
por: Abraham, Nikita, et al.
Publicado: (2017)

Discovery of a Potent and Selective α3β4 Nicotinic Acetylcholine Receptor Antagonist from an α-Conotoxin Synthetic Combinatorial Library
por: Chang, Yi-Pin, et al.
Publicado: (2014)

Identification of Crucial Residues in α-Conotoxin EI Inhibiting Muscle Nicotinic Acetylcholine Receptor
por: Ning, Jiong, et al.
Publicado: (2019)

Mechanism of interactions between α-conotoxin RegIIA and carbohydrates at the human α3β4 nicotinic acetylcholine receptor
por: Zheng, Meiling, et al.
Publicado: (2021)

Conotoxins Targeting Nicotinic Acetylcholine Receptors: An Overview
por: Lebbe, Eline K. M., et al.
Publicado: (2014)

αM-Conotoxin MIIIJ Blocks Nicotinic Acetylcholine Receptors at Neuromuscular Junctions of Frog and Fish
por: Rybin, Matthew J., et al.
Publicado: (2020)

Role of Cys(I)–Cys(III) Disulfide Bond on the Structure and Activity of α-Conotoxins at Human Neuronal Nicotinic Acetylcholine Receptors
por: Tabassum, Nargis, et al.
Publicado: (2017)

Effect of Methionine Oxidation and Substitution of α-Conotoxin TxID on α3β4 Nicotinic Acetylcholine Receptor
por: Ren, Jie, et al.
Publicado: (2018)

Synthetic α-Conotoxin Mutants as Probes for Studying Nicotinic Acetylcholine Receptors and in the Development of Novel Drug Leads
por: Armishaw, Christopher J.
Publicado: (2010)

Nicotinic Acetylcholine Receptor α9 and α10 Subunits Are Expressed in the Brain of Mice
por: Lykhmus, Olena, et al.
Publicado: (2017)

Blockade of Human α7 Nicotinic Acetylcholine Receptor by α-Conotoxin ImI Dendrimer: Insight from Computational Simulations
por: Xu, Xiaoxiao, et al.
Publicado: (2019)

The 3/4- and 3/6-Subfamily Variants of α-Conotoxins GI and MI Exhibit Potent Inhibitory Activity against Muscular Nicotinic Acetylcholine Receptors
por: Ma, Xiaoli, et al.
Publicado: (2021)

Fluorescently Labeled α-Conotoxin TxID, a New Probe for α3β4 Neuronal Nicotinic Acetylcholine Receptors
por: Huang, Meiling, et al.
Publicado: (2022)

Differential Expression of Nicotine Acetylcholine Receptors Associates with Human Breast Cancer and Mediates Antitumor Activity of αO-Conotoxin GeXIVA
por: Sun, Zhihua, et al.
Publicado: (2020)

Commentary: Nicotinic Acetylcholine Receptor α9 and α10 Subunits Are Expressed in the Brain of Mice
por: Morley, Barbara J., et al.
Publicado: (2018)

Differential Contribution of Subunit Interfaces to α9α10 Nicotinic Acetylcholine Receptor Function
por: Boffi, Juan Carlos, et al.
Publicado: (2017)

Interactions of the α3β2 Nicotinic Acetylcholine Receptor Interfaces with α-Conotoxin LsIA and its Carboxylated C-terminus Analogue: Molecular Dynamics Simulations
por: Wen, Jierong, et al.
Publicado: (2020)

Effects of C-Terminal Carboxylation on α-Conotoxin LsIA Interactions with Human α7 Nicotinic Acetylcholine Receptor: Molecular Simulation Studies
por: Wen, Jierong, et al.
Publicado: (2019)

Characterization of an α 4/7-Conotoxin LvIF from Conus lividus That Selectively Blocks α3β2 Nicotinic Acetylcholine Receptor
por: Guo, Man, et al.
Publicado: (2021)

Molecular Determinants of Species Specificity of α-Conotoxin TxIB towards Rat and Human α6/α3β4 Nicotinic Acetylcholine Receptors
por: Xie, Ting, et al.
Publicado: (2023)

Crystal Structure of the Monomeric Extracellular Domain of α9 Nicotinic Receptor Subunit in Complex With α-Conotoxin RgIA: Molecular Dynamics Insights Into RgIA Binding to α9α10 Nicotinic Receptors
por: Zouridakis, Marios, et al.
Publicado: (2019)

The Hair Cell α9α10 Nicotinic Acetylcholine Receptor: Odd Cousin in an Old Family
por: Lipovsek, Marcela, et al.
Publicado: (2021)

Corrigendum: Crystal structure of the monomeric extracellular domain of α9 nicotinic receptor subunit in complex with α-conotoxin RgIA: Molecular dynamics insights into RgIA binding to α9α10 nicotinic receptors
por: Zouridakis, Marios, et al.
Publicado: (2022)

α-Conotoxin TxIB: A Uniquely Selective Ligand for α6/α3β2β3 Nicotinic Acetylcholine Receptor Attenuates Nicotine-Induced Conditioned Place Preference in Mice
por: You, Shen, et al.
Publicado: (2019)

α-Conotoxin TxIB Inhibits Development of Morphine-Induced Conditioned Place Preference in Mice via Blocking α6β2* Nicotinic Acetylcholine Receptors
por: Li, Xiaodan, et al.
Publicado: (2021)

A Novel α4/7-Conotoxin QuIA Selectively Inhibits α3β2 and α6/α3β4 Nicotinic Acetylcholine Receptor Subtypes with High Efficacy
por: Wang, Liujun, et al.
Publicado: (2022)

Attenuation in Nicotinic Acetylcholine Receptor α9 and α10 Subunit Double Knock-Out Mice of Experimental Autoimmune Encephalomyelitis
por: Liu, Qiang, et al.
Publicado: (2019)

α7- and α9-Containing Nicotinic Acetylcholine Receptors in the Functioning of Immune System and in Pain
por: Shelukhina, Irina, et al.
Publicado: (2023)

Substitution of D-Arginine at Position 11 of α-RgIA Potently Inhibits α7 Nicotinic Acetylcholine Receptor
por: Wu, Yong, et al.
Publicado: (2023)

Alanine-Scanning Mutagenesis of α-Conotoxin GI Reveals the Residues Crucial for Activity at the Muscle Acetylcholine Receptor
por: Ning, Jiong, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_i7hotnc0p5c4mnf8iioig368hh