Cargando…

Limitations of the hCMEC/D3 cell line as a model for Aβ clearance by the human blood‐brain barrier

Alzheimer's disease and cerebral amyloid angiopathy are characterized by accumulation of amyloid‐β (Aβ) at the cerebrovasculature due to decreased clearance at the blood‐brain barrier (BBB). However, the exact mechanism of Aβ clearance across this barrier has not been fully elucidated. The hCME...

Descripción completa

Detalles Bibliográficos
Autores principales:	Biemans, Elisanne A.L.M., Jäkel, Lieke, de Waal, Robert M.W., Kuiperij, H. Bea, Verbeek, Marcel M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484315/ https://www.ncbi.nlm.nih.gov/pubmed/27726164 http://dx.doi.org/10.1002/jnr.23964

Ejemplares similares

Reduced Influence of apoE on Aβ43 Aggregation and Reduced Vascular Aβ43 Toxicity as Compared with Aβ40 and Aβ42
por: Jäkel, Lieke, et al.
Publicado: (2020)

The hCMEC/D3 cell line as a model of the human blood brain barrier
por: Weksler, Babette, et al.
Publicado: (2013)

Impact of altered glycaemia on blood-brain barrier endothelium: an in vitro study using the hCMEC/D3 cell line
por: Sajja, Ravi K, et al.
Publicado: (2014)

Aβ-Induced Damage Memory in hCMEC/D3 Cells Mediated by Sirtuin-1
por: Liu, Haochen, et al.
Publicado: (2020)

A Proton-Coupled Transport System for β-Hydroxy-β-Methylbutyrate (HMB) in Blood–Brain Barrier Endothelial Cell Line hCMEC/D3
por: Higuchi, Kei, et al.
Publicado: (2021)

The endo-lysosomal system of bEnd.3 and hCMEC/D3 brain endothelial cells
por: Toth, Andrea E., et al.
Publicado: (2019)

Cytokine-induced changes in the gene expression profile of a human cerebral microvascular endothelial cell-line, hCMEC/D3
por: Lopez-Ramirez, Miguel Alejandro, et al.
Publicado: (2013)

Effect of Withanolide A on 7-Ketocholesterol Induced Cytotoxicity in hCMEC/D3 Brain Endothelial Cells
por: Soh, Sandra, et al.
Publicado: (2022)

Pharmacophore-Based Discovery of Substrates of a Novel Drug/Proton-Antiporter in the Human Brain Endothelial hCMEC/D3 Cell Line
por: Smirnova, Maria, et al.
Publicado: (2022)

Exposure of human cerebral microvascular endothelial cells hCMEC/D3 to laminar shear stress induces vascular protective responses
por: Choublier, Nina, et al.
Publicado: (2022)

Protective Effect of Ergothioneine against 7-Ketocholesterol-Induced Mitochondrial Damage in hCMEC/D3 Human Brain Endothelial Cells
por: Leow, Damien Meng-Kiat, et al.
Publicado: (2023)

MicroRNA-29a Is a Candidate Biomarker for Alzheimer’s Disease in Cell-Free Cerebrospinal Fluid
por: Müller, Mareike, et al.
Publicado: (2015)

Functional expression of a proton-coupled organic cation (H(+)/OC) antiporter in human brain capillary endothelial cell line hCMEC/D3, a human blood–brain barrier model
por: Shimomura, Keita, et al.
Publicado: (2013)

The Novel lncRNA ENST00000530525 Affects ANO1, Contributing to Blood–Brain Barrier Injury in Cultured hCMEC/D3 Cells Under OGD/R Conditions
por: Jiang, Wen, et al.
Publicado: (2022)

Allyl Isothiocianate Induces Ca(2+) Signals and Nitric Oxide Release by Inducing Reactive Oxygen Species Production in the Human Cerebrovascular Endothelial Cell Line hCMEC/D3
por: Berra-Romani, Roberto, et al.
Publicado: (2023)

Hypoxia alters the expression of ACE2 and TMPRSS2 SARS-CoV-2 cell entry mediators in hCMEC/D3 brain endothelial cells
por: Imperio, Guinever E., et al.
Publicado: (2021)

Micellar Nanocarriers of Hydroxytyrosol Are Protective against Parkinson’s Related Oxidative Stress in an In Vitro hCMEC/D3-SH-SY5Y Co-Culture System
por: Mursaleen, Leah, et al.
Publicado: (2021)

A face-to-face comparison of claudin-5 transduced human brain endothelial (hCMEC/D3) cells with porcine brain endothelial cells as blood–brain barrier models for drug transport studies
por: Gericke, Birthe, et al.
Publicado: (2020)

Propofol attenuated TNF-α-modulated occludin expression by inhibiting Hif-1α/ VEGF/ VEGFR-2/ ERK signaling pathway in hCMEC/D3 cells
por: Zhang, Yue, et al.
Publicado: (2019)

Comparative study of four immortalized human brain capillary endothelial cell lines, hCMEC/D3, hBMEC, TY10, and BB19, and optimization of culture conditions, for an in vitro blood–brain barrier model for drug permeability studies
por: Eigenmann, Daniela E, et al.
Publicado: (2013)

NADPH Oxidase 5 (NOX5) Overexpression Promotes Endothelial Dysfunction via Cell Apoptosis, Migration, and Metabolic Alterations in Human Brain Microvascular Endothelial Cells (hCMEC/D3)
por: Marqués, Javier, et al.
Publicado: (2022)

A multifunctional ELISA to measure oxidised proteins: oxPin1 in Alzheimer's brain as an example
por: Herbert, Megan K., et al.
Publicado: (2015)

Analysis of L-leucine amino acid transporter species activity and gene expression by human blood brain barrier hCMEC/D3 model reveal potential LAT1, LAT4, B(0)AT2 and y(+)LAT1 functional cooperation
por: Taslimifar, Mehdi, et al.
Publicado: (2021)

Disturbed balance in the expression of MMP9 and TIMP3 in cerebral amyloid angiopathy-related intracerebral haemorrhage
por: Jäkel, Lieke, et al.
Publicado: (2020)

Heat Shock Proteins and Amateur Chaperones in Amyloid-Beta Accumulation and Clearance in Alzheimer’s Disease
por: Wilhelmus, Micha M. M., et al.
Publicado: (2007)

Aβ43 in human Alzheimer’s disease: effects of active Aβ42 immunization
por: Jäkel, Lieke, et al.
Publicado: (2019)

Activation of TNF Receptor 2 Improves Synaptic Plasticity and Enhances Amyloid-β Clearance in an Alzheimer’s Disease Mouse Model with Humanized TNF Receptor 2
por: Ortí-Casañ, Natalia, et al.
Publicado: (2023)

Cohort Profile: the China Multi-Ethnic Cohort (CMEC) study
por: Zhao, Xing, et al.
Publicado: (2020)

Decreased ratios of matrix metalloproteinases to tissue-type inhibitors in cerebrospinal fluid in sporadic and hereditary cerebral amyloid angiopathy
por: Vervuurt, Marc, et al.
Publicado: (2023)

Cerebrospinal Fluid Panel of Synaptic Proteins in Cerebral Amyloid Angiopathy and Alzheimer’s Disease
por: van den Berg, Emma, et al.
Publicado: (2023)

Plasma amyloid beta 42 is a biomarker for patients with hereditary, but not sporadic, cerebral amyloid angiopathy
por: de Kort, Anna M., et al.
Publicado: (2023)

Deciphering the Role of Extracellular Vesicles Derived from ZIKV-Infected hcMEC/D3 Cells on the Blood–Brain Barrier System
por: Fikatas, Antonios, et al.
Publicado: (2021)

Sufentanil ameliorates oxygen-glucose deprivation/reoxygenation-induced endothelial barrier dysfunction in HCMECs via the PI3K/Akt signaling pathway
por: Wang, Lianggang, et al.
Publicado: (2022)

Mst1 inhibits CMECs autophagy and participates in the development of diabetic coronary microvascular dysfunction
por: Lin, Jie, et al.
Publicado: (2016)

Cerebrospinal fluid monocyte chemoattractant protein 1 correlates with progression of Parkinson’s disease
por: Santaella, Anna, et al.
Publicado: (2020)

Inflammation biomarker discovery in Parkinson’s disease and atypical parkinsonisms
por: Santaella, Anna, et al.
Publicado: (2020)

CSF Neurofilament Light Chain but not FLT3 Ligand Discriminates Parkinsonian Disorders
por: Herbert, Megan K., et al.
Publicado: (2015)

Plin5/p-Plin5 Guards Diabetic CMECs by Regulating FFAs Metabolism Bidirectionally
por: Du, Jin, et al.
Publicado: (2019)

miR‐221‐3p targets Ang‐2 to inhibit the transformation of HCMECs to tip cells
por: Yang, Peng, et al.
Publicado: (2023)

MicroRNAs in Cerebrospinal Fluid as Potential Biomarkers for Parkinson’s Disease and Multiple System Atrophy
por: Marques, Tainá M., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_2s71913q2bl1e39b35lro05fkh