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Stereocontrolled Total Synthesis of (−)‐Stemaphylline

Homologation of readily available α‐boryl pyrrolidines with metal carbenoids is especially challenging even when good leaving groups (Cl(−)) are employed. By performing a solvent switch from Et(2)O to CHCl(3), efficient 1,2‐metalate rearrangement of the intermediate boronate occurs with both halide...

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Detalles Bibliográficos
Autores principales: Varela, Ana, Garve, Lennart K. B., Leonori, Daniele, Aggarwal, Varinder K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484348/
https://www.ncbi.nlm.nih.gov/pubmed/28097799
http://dx.doi.org/10.1002/anie.201611273