Differential induction of apoptosis and autophagy by pyrrolizidine alkaloid clivorine in human hepatoma Huh-7.5 cells and its toxic implication

Growing evidence suggests that the pyrrolizidine alkaloids (PAs)-induced hepatotoxicity is mediated by multiple cell death/defence modalities. However, the detailed mechanisms are still lacking. In this study, the hepatotoxic effects of four PAs including three retronecine-type ones (senecionine, se...

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Detalles Bibliográficos
Autores principales: Liu, Wenju, Li, Xu, Zhou, Bo, Fang, Shoucai, Ho, Wenzhe, Chen, Hui, Liang, Hao, Ye, Li, Tang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484491/
https://www.ncbi.nlm.nih.gov/pubmed/28650983
http://dx.doi.org/10.1371/journal.pone.0179379

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484491/
https://www.ncbi.nlm.nih.gov/pubmed/28650983
http://dx.doi.org/10.1371/journal.pone.0179379

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