Intranasal agomelatine solid lipid nanoparticles to enhance brain delivery: formulation, optimization and in vivo pharmacokinetics

PURPOSE: Agomelatine is a novel antidepressant drug suffering from an extensive first-pass metabolism leading to a diminished absolute bioavailability. The aim of the study is: first to enhance its absolute bioavailability, and second to increase its brain delivery. METHODS: To achieve these aims, t...

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Detalles Bibliográficos
Autores principales: Fatouh, Ahmed M, Elshafeey, Ahmed H, Abdelbary, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484509/
https://www.ncbi.nlm.nih.gov/pubmed/28684900
http://dx.doi.org/10.2147/DDDT.S102500

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484509/
https://www.ncbi.nlm.nih.gov/pubmed/28684900
http://dx.doi.org/10.2147/DDDT.S102500

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