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Intranasal agomelatine solid lipid nanoparticles to enhance brain delivery: formulation, optimization and in vivo pharmacokinetics

PURPOSE: Agomelatine is a novel antidepressant drug suffering from an extensive first-pass metabolism leading to a diminished absolute bioavailability. The aim of the study is: first to enhance its absolute bioavailability, and second to increase its brain delivery. METHODS: To achieve these aims, t...

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Detalles Bibliográficos
Autores principales:	Fatouh, Ahmed M, Elshafeey, Ahmed H, Abdelbary, Ahmed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484509/ https://www.ncbi.nlm.nih.gov/pubmed/28684900 http://dx.doi.org/10.2147/DDDT.S102500

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