Virtual screening for potential inhibitors of Mcl-1 conformations sampled by normal modes, molecular dynamics, and nuclear magnetic resonance

Myeloid cell leukemia-1 (Mcl-1) is often overexpressed in human cancer and is an important target for developing antineoplastic drugs. In this study, a data set containing 2.3 million lead-like molecules and a data set of all the US Food and Drug Administration (FDA)-approved drugs are virtually scr...

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Detalles Bibliográficos
Autores principales: Glantz-Gashai, Yitav, Meirson, Tomer, Reuveni, Eli, Samson, Abraham O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484510/
https://www.ncbi.nlm.nih.gov/pubmed/28684899
http://dx.doi.org/10.2147/DDDT.S133127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484510/
https://www.ncbi.nlm.nih.gov/pubmed/28684899
http://dx.doi.org/10.2147/DDDT.S133127

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