Human in vitro-induced regulatory T cells display Dlgh1 dependent and PKC-θ restrained suppressive activity

In vitro induced human regulatory T cells (iTregs) have demonstrated in vivo therapeutic utility, but pathways regulating their function have not been elucidated. Here, we report that human iTregs generated in vitro from naïve cord blood cells preferentially recruit Disc large homolog 1 (Dlgh1) and...

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Detalles Bibliográficos
Autores principales: Zanin-Zhorov, Alexandra, Kumari, Sudha, Hippen, Keli L., Merkel, Sarah C., MacMillan, Margaret L., Blazar, Bruce R., Dustin, Michael L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484704/
https://www.ncbi.nlm.nih.gov/pubmed/28652577
http://dx.doi.org/10.1038/s41598-017-04053-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484704/
https://www.ncbi.nlm.nih.gov/pubmed/28652577
http://dx.doi.org/10.1038/s41598-017-04053-5

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