Development of a common carp (Cyprinus carpio) pregnane X receptor (cPXR) transactivation reporter assay and its activation by azole fungicides and pharmaceutical chemicals

In mammals, the pregnane X receptor (PXR) is a transcription factor with a key role in regulating expression of several genes involved in drug biotransformation. PXR is present in fish and some genes known to be under its control can be up-regulated by mammalian PXR ligands. Despite this, direct inv...

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Detalles Bibliográficos
Autores principales: Lange, Anke, Corcoran, Jenna, Miyagawa, Shinichi, Iguchi, Taisen, Winter, Matthew J., Tyler, Charles R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484788/
https://www.ncbi.nlm.nih.gov/pubmed/28259787
http://dx.doi.org/10.1016/j.tiv.2017.02.023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484788/
https://www.ncbi.nlm.nih.gov/pubmed/28259787
http://dx.doi.org/10.1016/j.tiv.2017.02.023

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