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Model‐based investigation of intracellular processes determining antibody Fc‐glycosylation under mild hypothermia
Despite the positive effects of mild hypothermic conditions on monoclonal antibody (mAb) productivity (q (mAb)) during mammalian cell culture, the impact of reduced culture temperature on mAb Fc‐glycosylation and the mechanism behind changes in the glycan composition are not fully established. The l...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485029/ https://www.ncbi.nlm.nih.gov/pubmed/27869292 http://dx.doi.org/10.1002/bit.26225 |