Activation of the c‐Jun N‐terminal kinase pathway aggravates proteotoxicity of hepatic mutant Z alpha1‐antitrypsin

Alpha1‐antitrypsin deficiency is a genetic disease that can affect both the lung and the liver. The vast majority of patients harbor a mutation in the serine protease inhibitor 1A (SERPINA1) gene leading to a single amino acid substitution that results in an unfolded protein that is prone to polymer...

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Detalles Bibliográficos
Autores principales: Pastore, Nunzia, Attanasio, Sergio, Granese, Barbara, Castello, Raffaele, Teckman, Jeffrey, Wilson, Andrew A., Ballabio, Andrea, Brunetti‐Pierri, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Steatohepatitis/Metabolic Liver Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485069/
https://www.ncbi.nlm.nih.gov/pubmed/28073160
http://dx.doi.org/10.1002/hep.29035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485069/
https://www.ncbi.nlm.nih.gov/pubmed/28073160
http://dx.doi.org/10.1002/hep.29035

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