Effects of lysosomal biotherapeutic recombinant protein expression on cell stress and protease and general host cell protein release in Chinese hamster ovary cells

Recombinant human Acid Alpha Glucosidase (GAA) is the therapeutic enzyme used for the treatment of Pompe disease, a rare genetic disorder characterized by GAA deficiency in the cell lysosomes (Raben et al., Curr Mol Med. 2002; 2:145–166). The manufacturing process for GAA can be challenging, in part...

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Detalles Bibliográficos
Autores principales: Migani, Damiano, Smales, C. Mark, Bracewell, Daniel G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
RESEARCH ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485175/
https://www.ncbi.nlm.nih.gov/pubmed/28249362
http://dx.doi.org/10.1002/btpr.2455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485175/
https://www.ncbi.nlm.nih.gov/pubmed/28249362
http://dx.doi.org/10.1002/btpr.2455

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