Cargando…

c-Myc is Required for BRAF(V600E)-Induced Epigenetic Silencing by H3K27me3 in Tumorigenesis

BRAF(V600E) mutation is frequently found in human cancers particularly thyroid cancer and melanoma, and is involved in the regulation of gene expression through activating MAPK/Erk signaling. Trimethylation of histone 3 lysine 27 (H3K27me3) is a critical epigenetic mark for the maintenance of gene s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qu, Yiping, Yang, Qi, Liu, Juan, Shi, Bingyin, Ji, Meiju, Li, Gang, Hou, Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485424/ https://www.ncbi.nlm.nih.gov/pubmed/28656062 http://dx.doi.org/10.7150/thno.19884

Ejemplares similares

Transposon Mutagenesis Reveals RBMS3 Silencing as a Promoter of Malignant Progression of BRAF(V600E)-Driven Lung Tumorigenesis
por: Vaishnavi, Aria, et al.
Publicado: (2022)

Analysis of BRAF(V600E) mutation and DNA methylation improves the diagnostics of thyroid fine needle aspiration biopsies
por: Zhang, Bingfei, et al.
Publicado: (2014)

Epigenetic engineering shows that a human centromere resists silencing mediated by H3K27me3/K9me3
por: Martins, Nuno M. C., et al.
Publicado: (2016)

EZH2 dependent H3K27me3 is involved in epigenetic silencing of ID4 in prostate cancer
por: Chinaranagari, Swathi, et al.
Publicado: (2014)

SMAD4 is Critical in Suppression of BRAF-V600E Serrated Tumorigenesis
por: Tong, Kevin, et al.
Publicado: (2021)

BRaf(V600E) cooperates with Pten silencing to elicit metastatic melanoma
por: Dankort, David, et al.
Publicado: (2009)

Histone Demethylases as Counterbalance to H3K27me3 Silencing in Plants
por: Crevillén, Pedro
Publicado: (2020)

Copper is required for oncogenic BRAF signaling and tumorigenesis
por: Brady, Donita C., et al.
Publicado: (2014)

Zinc finger protein 280C contributes to colorectal tumorigenesis by maintaining epigenetic repression at H3K27me3-marked loci
por: Ying, Ying, et al.
Publicado: (2022)

BRAF(V600E) cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis
por: Sakamoto, Naoya, et al.
Publicado: (2017)

Synergistic activation of mutant TERT promoter by Sp1 and GABPA in BRAF(V600E)-driven human cancers
por: Wu, Yongxing, et al.
Publicado: (2021)

Simultaneous Hodgkin lymphoma and BRAF(V600E)-positive papillary thyroid carcinoma: A case report
por: Liu, Shu, et al.
Publicado: (2019)

Restoration of H3k27me3 Modification Epigenetically Silences Cry1 Expression and Sensitizes Leptin Signaling to Reduce Obesity‐Related Properties
por: Wei, Yan, et al.
Publicado: (2021)

H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis
por: Harutyunyan, Ashot S., et al.
Publicado: (2019)

Increased expression of EHF contributes to thyroid tumorigenesis through transcriptionally regulating HER2 and HER3
por: Lv, Yanyan, et al.
Publicado: (2016)

BRAF(V600E) protein expression and outcome from BRAF inhibitor treatment in BRAF(V600E) metastatic melanoma
por: Wilmott, J S, et al.
Publicado: (2013)

CYP2S1 is a synthetic lethal target in BRAF(V600E)-driven thyroid cancers
por: Li, Yiqi, et al.
Publicado: (2020)

PRC2 is required for extensive reorganization of H3K27me3 during epigenetic reprogramming in mouse fetal germ cells
por: Prokopuk, Lexie, et al.
Publicado: (2017)

[600 MeV]
por: CERN Press Office. Geneva
Publicado: (1962)

Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer
por: Pajovic, Sanja, et al.
Publicado: (2020)

BRAF V600E Inhibitor (Vemurafenib) for BRAF V600E Mutated Low Grade Gliomas
por: Del Bufalo, Francesca, et al.
Publicado: (2018)

Global analysis of H3K27me3 as an epigenetic marker in prostate cancer progression
por: Ngollo, Marjolaine, et al.
Publicado: (2017)

BPTF is required for c-MYC transcriptional activity and in vivo tumorigenesis
por: Richart, Laia, et al.
Publicado: (2016)

Histone deacetylation of NIS promoter underlies BRAF V600E-promoted NIS silencing in thyroid cancer
por: Zhang, Zongjing, et al.
Publicado: (2014)

Antagonistic Roles for H3K36me3 and H3K27me3 in the Cold-Induced Epigenetic Switch at Arabidopsis FLC
por: Yang, Hongchun, et al.
Publicado: (2014)

A Genetic Progression Model of Braf(V600E)-Induced Intestinal Tumorigenesis Reveals Targets for Therapeutic Intervention
por: Rad, Roland, et al.
Publicado: (2013)

MiR-145 inhibits oral squamous cell carcinoma (OSCC) cell growth by targeting c-Myc and Cdk6
por: Shao, Yuan, et al.
Publicado: (2013)

The role of BRAF V600 mutation in melanoma
por: Ascierto, Paolo A, et al.
Publicado: (2012)

Epigenetic drift of H3K27me3 in aging links glycolysis to healthy longevity in Drosophila
por: Ma, Zaijun, et al.
Publicado: (2018)

TERT promoter mutations and long telomere length predict poor survival and radiotherapy resistance in gliomas
por: Gao, Ke, et al.
Publicado: (2015)

A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing
por: Fan, Huitao, et al.
Publicado: (2021)

Acquired resistance to BRAF inhibition in BRAF(V600E) mutant gliomas
por: Yao, Tsun-Wen, et al.
Publicado: (2016)

RMEL3, a novel BRAF(V600E)-associated long noncoding RNA, is required for MAPK and PI3K signaling in melanoma
por: Goedert, Lucas, et al.
Publicado: (2016)

Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner
por: Cano-Rodriguez, David, et al.
Publicado: (2016)

HGG-49. A PEDIATRIC THALAMIC HIGH-GRADE GLIOMA WITH H3F3A K27M AND BRAF V600E DOUBLE MUTATIONS
por: Terashima, Keita, et al.
Publicado: (2020)

SMC3 epigenetic silencing regulates Rab27a expression and drives pancreatic cancer progression
por: Bastos, Nuno, et al.
Publicado: (2023)

Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3
por: Prickaerts, Peggy, et al.
Publicado: (2016)

Epigenetic reprogramming of H3K27me3 and DNA methylation during leaf-to-callus transition in peach
por: Zheng, Beibei, et al.
Publicado: (2022)

In-depth genomic data analyses revealed complex transcriptional and epigenetic dysregulations of BRAF(V600E) in melanoma
por: Guo, Xingyi, et al.
Publicado: (2015)

Epigenetic inhibitors eliminate senescent melanoma BRAFV600E cells that survive long-term BRAF inhibition
por: Rowdo, Florencia Paula Madorsky, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_s9tnl6ikmgo1m5v2r1r4e75ot4