Organelle acidification: an ancient cellular leak detector

Intracellular membrane-bounded organelles of eukaryotic cells transiently contact the extracellular environment during endocytosis and secretion. Such contacts must be precisely timed to prevent leakage of cargo. I argue that early eukaryotes evolved organelle acidification as a way to detect and pr...

Descripción completa

Detalles Bibliográficos
Autor principal: Thattai, Mukund
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485493/
https://www.ncbi.nlm.nih.gov/pubmed/28651577
http://dx.doi.org/10.1186/s12915-017-0395-1
_version_ 1783246075178516480
author Thattai, Mukund
author_facet Thattai, Mukund
author_sort Thattai, Mukund
collection PubMed
description Intracellular membrane-bounded organelles of eukaryotic cells transiently contact the extracellular environment during endocytosis and secretion. Such contacts must be precisely timed to prevent leakage of cargo. I argue that early eukaryotes evolved organelle acidification as a way to detect and prevent leakage.
format Online
Article
Text
id pubmed-5485493
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-54854932017-06-30 Organelle acidification: an ancient cellular leak detector Thattai, Mukund BMC Biol Comment Intracellular membrane-bounded organelles of eukaryotic cells transiently contact the extracellular environment during endocytosis and secretion. Such contacts must be precisely timed to prevent leakage of cargo. I argue that early eukaryotes evolved organelle acidification as a way to detect and prevent leakage. BioMed Central 2017-06-26 /pmc/articles/PMC5485493/ /pubmed/28651577 http://dx.doi.org/10.1186/s12915-017-0395-1 Text en © Thattai et al. 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Comment
Thattai, Mukund
Organelle acidification: an ancient cellular leak detector
title Organelle acidification: an ancient cellular leak detector
title_full Organelle acidification: an ancient cellular leak detector
title_fullStr Organelle acidification: an ancient cellular leak detector
title_full_unstemmed Organelle acidification: an ancient cellular leak detector
title_short Organelle acidification: an ancient cellular leak detector
title_sort organelle acidification: an ancient cellular leak detector
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485493/
https://www.ncbi.nlm.nih.gov/pubmed/28651577
http://dx.doi.org/10.1186/s12915-017-0395-1
work_keys_str_mv AT thattaimukund organelleacidificationanancientcellularleakdetector

Ejemplares similares