Development and validation of a variant detection workflow for BRCA1 and BRCA2 genes and its clinical application based on the Ion Torrent technology

BACKGROUND: Breast cancer is the most common among women worldwide, and ovarian cancer is the most difficult gynecological tumor to diagnose and with the lowest chance of cure. Mutations in BRCA1 and BRCA2 genes increase the risk of ovarian cancer by 60% and breast cancer by up to 80% in women. Mole...

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Detalles Bibliográficos
Autores principales: Buzolin, Ana Lígia, Moreira, Caroline Mônaco, Sacramento, Patricia Rossi, Oku, Andre Yuji, Fornari, Alexandre Ricardo dos Santos, Antonio, David Santos Marco, Quaio, Caio Robledo D Angioli Costa, Baratela, Wagner Rosa, Mitne-Neto, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485501/
https://www.ncbi.nlm.nih.gov/pubmed/28651617
http://dx.doi.org/10.1186/s40246-017-0110-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485501/
https://www.ncbi.nlm.nih.gov/pubmed/28651617
http://dx.doi.org/10.1186/s40246-017-0110-x

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