Synthesis and Thrombin, Factor Xa and U46619 Inhibitory Effects of Non-Amidino and Amidino N(2)-Thiophenecarbonyl- and N(2)-Tosylanthranilamides

Thrombin (factor IIa) and factor Xa (FXa) are key enzymes at the junction of the intrinsic and extrinsic coagulation pathways and are the most attractive pharmacological targets for the development of novel anticoagulants. Twenty non-amidino N(2)-thiophencarbonyl- and N(2)-tosyl anthranilamides 1–20...

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Detalles Bibliográficos
Autores principales: Lee, Soo Hyun, Lee, Wonhwa, Nguyen, ThiHa, Um, Il Soo, Bae, Jong-Sup, Ma, Eunsook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485968/
https://www.ncbi.nlm.nih.gov/pubmed/28561744
http://dx.doi.org/10.3390/ijms18061144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485968/
https://www.ncbi.nlm.nih.gov/pubmed/28561744
http://dx.doi.org/10.3390/ijms18061144

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