Friction-Induced Mitochondrial Dysregulation Contributes to Joint Deterioration in Prg4 Knockout Mice

Deficiency of PRG4 (lubricin), the boundary lubricant in mammalian joints, contributes to increased joint friction accompanied by superficial and upper intermediate zone chondrocyte caspase-3 activation, as shown in lubricin-null (Prg4(−/−)) mice. Caspase-3 activity appears to be reversible upon the...

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Detalles Bibliográficos
Autores principales: Waller, Kimberly A., Zhang, Ling X., Jay, Gregory D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486075/
https://www.ncbi.nlm.nih.gov/pubmed/28604608
http://dx.doi.org/10.3390/ijms18061252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486075/
https://www.ncbi.nlm.nih.gov/pubmed/28604608
http://dx.doi.org/10.3390/ijms18061252

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