α-Synuclein binds to the ER–mitochondria tethering protein VAPB to disrupt Ca(2+) homeostasis and mitochondrial ATP production

α-Synuclein is strongly linked to Parkinson’s disease but the molecular targets for its toxicity are not fully clear. However, many neuronal functions damaged in Parkinson’s disease are regulated by signalling between the endoplasmic reticulum (ER) and mitochondria. This signalling involves close ph...

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Detalles Bibliográficos
Autores principales: Paillusson, Sébastien, Gomez-Suaga, Patricia, Stoica, Radu, Little, Daniel, Gissen, Paul, Devine, Michael J., Noble, Wendy, Hanger, Diane P., Miller, Christopher C. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486644/
https://www.ncbi.nlm.nih.gov/pubmed/28337542
http://dx.doi.org/10.1007/s00401-017-1704-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486644/
https://www.ncbi.nlm.nih.gov/pubmed/28337542
http://dx.doi.org/10.1007/s00401-017-1704-z

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