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Human breast cancer cell-mediated bone collagen degradation requires plasminogen activation and matrix metalloproteinase activity
BACKGROUND: Breast cancer cells frequently metastasize to the skeleton and induce extensive bone destruction. Cancer cells produce proteinases, including matrix metalloproteinases (MMPs) and the plasminogen activator system (PAS) which promote invasion of extracellular matrices, but whether these pr...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2005
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC548674/ https://www.ncbi.nlm.nih.gov/pubmed/15701164 http://dx.doi.org/10.1186/1475-2867-5-1 |