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Insights into the prevalence and underlying causes of clonal variation through transcriptomic analysis in Pichia pastoris

Clonal variation, wherein a range of specific productivities of secreted proteins are observed from supposedly identical transformants, is an accepted aspect of working with Pichia pastoris. It means that a significant number of transformants need to be tested to obtain a representative sample, and...

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Detalles Bibliográficos
Autores principales: Aw, Rochelle, Barton, Geraint R, Leak, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486821/
https://www.ncbi.nlm.nih.gov/pubmed/28534062
http://dx.doi.org/10.1007/s00253-017-8317-2