A mathematical analysis of rebound in a target-mediated drug disposition model: II. With feedback

We consider the possibility of free receptor (antigen/cytokine) levels rebounding to higher than the baseline level after the application of an antibody drug using a target-mediated drug disposition model. It is assumed that the receptor synthesis rate experiences homeostatic feedback from the recep...

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Detalles Bibliográficos
Autores principales: Aston, Philip J., Derks, Gianne, Agoram, Balaji M., van der Graaf, Piet H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487209/
https://www.ncbi.nlm.nih.gov/pubmed/27832321
http://dx.doi.org/10.1007/s00285-016-1073-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487209/
https://www.ncbi.nlm.nih.gov/pubmed/27832321
http://dx.doi.org/10.1007/s00285-016-1073-6

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