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A mathematical analysis of rebound in a target-mediated drug disposition model: II. With feedback
We consider the possibility of free receptor (antigen/cytokine) levels rebounding to higher than the baseline level after the application of an antibody drug using a target-mediated drug disposition model. It is assumed that the receptor synthesis rate experiences homeostatic feedback from the recep...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487209/ https://www.ncbi.nlm.nih.gov/pubmed/27832321 http://dx.doi.org/10.1007/s00285-016-1073-6 |