Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy

Behavioral deficits in neurodegenerative diseases are often attributed to the selective dysfunction of vulnerable neurons via cell-autonomous mechanisms. Although vulnerable neurons are embedded in neuronal circuits, the contribution of their synaptic partners to the disease process is largely unkno...

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Detalles Bibliográficos
Autores principales: Fletcher, Emily V., Simon, Christian M., Pagiazitis, John G., Chalif, Joshua I., Vukojicic, Aleksandra, Drobac, Estelle, Wang, Xiaojian, Mentis, George Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487291/
https://www.ncbi.nlm.nih.gov/pubmed/28504671
http://dx.doi.org/10.1038/nn.4561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487291/
https://www.ncbi.nlm.nih.gov/pubmed/28504671
http://dx.doi.org/10.1038/nn.4561

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