Stat6 Promotes Intestinal Tumorigenesis in a Mouse Model of Adenomatous Polyposis by Expansion of MDSCs and Inhibition of Cytotoxic CD8 Response

Intestinal tumorigenesis in the ApcMin/+ model is initiated by aberrant activation of Wnt pathway. Increased IL-4 expression in human colorectal cancer tissue and growth of colon cancer cell lines implied that IL-4–induced Stat6-mediated tumorigenic signaling likely contributes to intestinal tumor p...

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Detalles Bibliográficos
Autores principales: Jayakumar, Asha, Bothwell, Alfred L.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2017
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487300/
https://www.ncbi.nlm.nih.gov/pubmed/28654863
http://dx.doi.org/10.1016/j.neo.2017.04.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487300/
https://www.ncbi.nlm.nih.gov/pubmed/28654863
http://dx.doi.org/10.1016/j.neo.2017.04.006

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