miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin

The B-lymphoma Moloney murine leukemia virus insertion region-1 protein (BMI1) acts as an oncogene in various cancers, including breast cancer. Recent evidence suggests that BMI1 is rapidly recruited to sites of DNA double strand breaks where it facilitates histone H2A ubiquitination and DNA double...

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Detalles Bibliográficos
Autores principales: Patel, Nibedita, Garikapati, Koteswara Rao, Pandita, Raj K., Singh, Dharmendra Kumar, Pandita, Tej K., Bhadra, Utpal, Bhadra, Manika Pal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487337/
https://www.ncbi.nlm.nih.gov/pubmed/28655885
http://dx.doi.org/10.1038/s41598-017-02800-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487337/
https://www.ncbi.nlm.nih.gov/pubmed/28655885
http://dx.doi.org/10.1038/s41598-017-02800-2

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