Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression

We have previously shown that glioblastoma stem cells (GSCs) are enriched in the hypoxic tumor microenvironment, and that monocarboxylate transporter-4 (MCT4) is critical for mediating GSC signaling in hypoxia. Basigin is involved in many physiological functions during early stages of development an...

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Detalles Bibliográficos
Autores principales: Voss, Dillon M., Spina, Raffaella, Carter, David L., Lim, Kah Suan, Jeffery, Constance J., Bar, Eli E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487345/
https://www.ncbi.nlm.nih.gov/pubmed/28655889
http://dx.doi.org/10.1038/s41598-017-04612-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487345/
https://www.ncbi.nlm.nih.gov/pubmed/28655889
http://dx.doi.org/10.1038/s41598-017-04612-w

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