Galactosylsphingamides: new α-GalCer analogues to probe the F’-pocket of CD1d

Invariant Natural Killer T-cells (iNKT-cells) are an attractive target for immune response modulation, as upon CD1d-mediated stimulation with KRN7000, a synthetic α-galactosylceramide, they produce a vast amount of cytokines. Here we present a synthesis that allows swift modification of the phytosph...

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Detalles Bibliográficos
Autores principales: Guillaume, Joren, Wang, Jing, Janssens, Jonas, Remesh, Soumya G., Risseeuw, Martijn D. P., Decruy, Tine, Froeyen, Mathy, Elewaut, Dirk, Zajonc, Dirk M., Calenbergh, Serge Van
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487351/
https://www.ncbi.nlm.nih.gov/pubmed/28655912
http://dx.doi.org/10.1038/s41598-017-04461-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487351/
https://www.ncbi.nlm.nih.gov/pubmed/28655912
http://dx.doi.org/10.1038/s41598-017-04461-7

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