Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer’s model mice

We examined the effect of chronic high fat diet (HFD) on amyloid deposition and cognition of 12-months old APP23 mice, and correlated the phenotype to brain transcriptome and lipidome. HFD significantly increased amyloid plaques and worsened cognitive performance compared to mice on normal diet (ND)...

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Detalles Bibliográficos
Autores principales: Nam, Kyong Nyon, Mounier, Anais, Wolfe, Cody M., Fitz, Nicholas F., Carter, Alexis Y., Castranio, Emilie L., Kamboh, Hafsa I., Reeves, Valerie L., Wang, Jianing, Han, Xianlin, Schug, Jonathan, Lefterov, Iliya, Koldamova, Radosveta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487356/
https://www.ncbi.nlm.nih.gov/pubmed/28655926
http://dx.doi.org/10.1038/s41598-017-04412-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487356/
https://www.ncbi.nlm.nih.gov/pubmed/28655926
http://dx.doi.org/10.1038/s41598-017-04412-2

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