Central Nervous System Infection with Borna Disease Virus Causes Kynurenine Pathway Dysregulation and Neurotoxic Quinolinic Acid Production

Central nervous system infection of neonatal and adult rats with Borna disease virus (BDV) results in neuronal destruction and behavioral abnormalities with differential immune-mediated involvement. Neuroactive metabolites generated from the kynurenine pathway of tryptophan degradation have been imp...

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Detalles Bibliográficos
Autores principales: Formisano, Simone, Hornig, Mady, Yaddanapudi, Kavitha, Vasishtha, Mansi, Parsons, Loren H., Briese, Thomas, Lipkin, W. Ian, Williams, Brent L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Cellular Response to Infection
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487560/
https://www.ncbi.nlm.nih.gov/pubmed/28446679
http://dx.doi.org/10.1128/JVI.00673-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487560/
https://www.ncbi.nlm.nih.gov/pubmed/28446679
http://dx.doi.org/10.1128/JVI.00673-17

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