ERG11 Gene Mutations and MDR1 Upregulation Confer Pan-Azole Resistance in Candida tropicalis Causing Disseminated Candidiasis in an Acute Lymphoblastic Leukemia Patient on Posaconazole Prophylaxis

In this study, we present a rare case of fatal breakthrough Candida tropicalis infection in a patient with acute lymphoblastic leukemia (ALL) while on posaconazole prophylaxis. Then, we explore the mechanisms underlying azole resistance by focusing on enhanced efflux pumps and changes in the azole t...

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Detalles Bibliográficos
Autores principales: You, Liangshun, Qian, Wenbin, Yang, Qing, Mao, Liping, Zhu, Li, Huang, Xianbo, Jin, Jie, Meng, Haitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487663/
https://www.ncbi.nlm.nih.gov/pubmed/28507109
http://dx.doi.org/10.1128/AAC.02496-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487663/
https://www.ncbi.nlm.nih.gov/pubmed/28507109
http://dx.doi.org/10.1128/AAC.02496-16

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