Elucidating the Aβ42 Anti-Aggregation Mechanism of Action of Tramiprosate in Alzheimer’s Disease: Integrating Molecular Analytical Methods, Pharmacokinetic and Clinical Data

BACKGROUND: Amyloid beta (Aβ) oligomers play a critical role in the pathogenesis of Alzheimer’s disease (AD) and represent a promising target for drug development. Tramiprosate is a small-molecule Aβ anti-aggregation agent that was evaluated in phase III clinical trials for AD but did not meet the p...

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Detalles Bibliográficos
Autores principales: Kocis, Petr, Tolar, Martin, Yu, Jeremy, Sinko, William, Ray, Soumya, Blennow, Kaj, Fillit, Howard, Hey, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488121/
https://www.ncbi.nlm.nih.gov/pubmed/28435985
http://dx.doi.org/10.1007/s40263-017-0434-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488121/
https://www.ncbi.nlm.nih.gov/pubmed/28435985
http://dx.doi.org/10.1007/s40263-017-0434-z

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