Bioluminescent Antibodies for Point‐of‐Care Diagnostics

We introduce a general method to transform antibodies into ratiometric, bioluminescent sensor proteins for the no‐wash quantification of analytes. Our approach is based on the genetic fusion of antibody fragments to NanoLuc luciferase and SNAP‐tag, the latter being labeled with a synthetic fluoresce...

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Detalles Bibliográficos
Autores principales: Xue, Lin, Yu, Qiuliyang, Griss, Rudolf, Schena, Alberto, Johnsson, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488172/
https://www.ncbi.nlm.nih.gov/pubmed/28510347
http://dx.doi.org/10.1002/anie.201702403

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488172/
https://www.ncbi.nlm.nih.gov/pubmed/28510347
http://dx.doi.org/10.1002/anie.201702403

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