Cargando…

A New Methodology for Incorporating Chiral Linkers into Stapled Peptides

Stapled peptides have arisen as a new class of chemical probe and potential therapeutic agents for modulating protein–protein interactions. Here, we report the first two‐component i,i+7 stapling methodology that makes use of two orthogonal, on‐resin stapling reactions to incorporate linkers bearing...

Descripción completa

Detalles Bibliográficos
Autores principales: Serrano, Juan C., Sipthorp, James, Xu, Wenshu, Itzhaki, Laura S., Ley, Steven V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488175/
https://www.ncbi.nlm.nih.gov/pubmed/28388005
http://dx.doi.org/10.1002/cbic.201700075