Modular Synthesis of Diverse Natural Product‐Like Macrocycles: Discovery of Hits with Antimycobacterial Activity

A modular synthetic approach was developed in which variation of the triplets of building blocks used enabled systematic variation of the macrocyclic scaffolds prepared. The approach was demonstrated in the synthesis of 17 diverse natural product‐like macrocyclic scaffolds of varied (12–20‐membered)...

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Detalles Bibliográficos
Autores principales: Dow, Mark, Marchetti, Francesco, Abrahams, Katherine A., Vaz, Luis, Besra, Gurdyal S., Warriner, Stuart, Nelson, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488202/
https://www.ncbi.nlm.nih.gov/pubmed/28374952
http://dx.doi.org/10.1002/chem.201701150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488202/
https://www.ncbi.nlm.nih.gov/pubmed/28374952
http://dx.doi.org/10.1002/chem.201701150

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