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BRIE: transcriptome-wide splicing quantification in single cells

Single-cell RNA-seq (scRNA-seq) provides a comprehensive measurement of stochasticity in transcription, but the limitations of the technology have prevented its application to dissect variability in RNA processing events such as splicing. Here, we present BRIE (Bayesian regression for isoform estima...

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Detalles Bibliográficos
Autores principales: Huang, Yuanhua, Sanguinetti, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488362/
https://www.ncbi.nlm.nih.gov/pubmed/28655331
http://dx.doi.org/10.1186/s13059-017-1248-5