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Mechanism-based selection of stabilization strategy for amorphous formulations: Insights into crystallization pathways

We developed a step-by-step experimental protocol using differential scanning calorimetry (DSC), dynamic vapour sorption (DVS), polarized light microscopy (PLM) and a small-scale dissolution apparatus (μDISS Profiler) to investigate the mechanism (solid-to-solid or solution-mediated) by which crysta...

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Detalles Bibliográficos
Autores principales: Edueng, Khadijah, Mahlin, Denny, Larsson, Per, Bergström, Christel A.S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Publishers 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488750/
https://www.ncbi.nlm.nih.gov/pubmed/28412224
http://dx.doi.org/10.1016/j.jconrel.2017.04.015