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Mechanism-based selection of stabilization strategy for amorphous formulations: Insights into crystallization pathways
We developed a step-by-step experimental protocol using differential scanning calorimetry (DSC), dynamic vapour sorption (DVS), polarized light microscopy (PLM) and a small-scale dissolution apparatus (μDISS Profiler) to investigate the mechanism (solid-to-solid or solution-mediated) by which crysta...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Science Publishers
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488750/ https://www.ncbi.nlm.nih.gov/pubmed/28412224 http://dx.doi.org/10.1016/j.jconrel.2017.04.015 |