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Sulfonyl fluorides as privileged warheads in chemical biology

Sulfonyl fluoride electrophiles have found significant utility as reactive probes in chemical biology and molecular pharmacology. As warheads they possess the right balance of biocompatibility (including aqueous stability) and protein reactivity. Their functionality is privileged in this regard as t...

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Detalles Bibliográficos
Autores principales: Narayanan, Arjun, Jones, Lyn H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489032/
https://www.ncbi.nlm.nih.gov/pubmed/28706662
http://dx.doi.org/10.1039/c5sc00408j