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Molecular glues for manipulating enzymes: trypsin inhibition by benzamidine-conjugated molecular glues
Water-soluble bioadhesive polymers bearing multiple guanidinium ion (Gu(+)) pendants at their side-chain termini (Glue(n)–BA, n = 10 and 29) that were conjugated with benzamidine (BA) as a trypsin inhibitor were developed. The Glue(n)–BA molecules are supposed to adhere to oxyanionic regions of the...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489047/ https://www.ncbi.nlm.nih.gov/pubmed/28706668 http://dx.doi.org/10.1039/c5sc00524h |