MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy

The “super-relaxed state” (SRX) of myosin represents a ‘reserve’ of motors in the heart. Myosin heads in the SRX are bound to the thick filament and have a very low ATPase rate. Changes in the SRX are likely to modulate cardiac contractility. We previously demonstrated that the SRX is significantly...

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Detalles Bibliográficos
Autores principales: McNamara, James W., Li, Amy, Lal, Sean, Bos, J. Martijn, Harris, Samantha P., van der Velden, Jolanda, Ackerman, Michael J., Cooke, Roger, dos Remedios, Cristobal G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489194/
https://www.ncbi.nlm.nih.gov/pubmed/28658286
http://dx.doi.org/10.1371/journal.pone.0180064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489194/
https://www.ncbi.nlm.nih.gov/pubmed/28658286
http://dx.doi.org/10.1371/journal.pone.0180064

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