A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism

Only one out of 10 drugs in development passes clinical trials. Many fail because experimental animal models poorly predict human xenobiotic metabolism. Human liver chimeric mice are a step forward in this regard, as the human hepatocytes in chimeric livers generate human metabolites, but the remain...

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Detalles Bibliográficos
Autores principales: Barzi, Mercedes, Pankowicz, Francis P., Zorman, Barry, Liu, Xing, Legras, Xavier, Yang, Diane, Borowiak, Malgorzata, Bissig-Choisat, Beatrice, Sumazin, Pavel, Li, Feng, Bissig, Karl-Dimiter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489481/
https://www.ncbi.nlm.nih.gov/pubmed/28659616
http://dx.doi.org/10.1038/s41467-017-00049-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489481/
https://www.ncbi.nlm.nih.gov/pubmed/28659616
http://dx.doi.org/10.1038/s41467-017-00049-x

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