Macrophage responses to lipopolysaccharide are modulated by a feedback loop involving prostaglandin E(2), dual specificity phosphatase 1 and tristetraprolin

In many different cell types, pro-inflammatory agonists induce the expression of cyclooxygenase 2 (COX-2), an enzyme that catalyzes rate-limiting steps in the conversion of arachidonic acid to a variety of lipid signaling molecules, including prostaglandin E(2) (PGE(2)). PGE(2) has key roles in many...

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Detalles Bibliográficos
Autores principales: Tang, Tina, Scambler, Thomas E., Smallie, Tim, Cunliffe, Helen E., Ross, Ewan A., Rosner, Dalya R., O’Neil, John D., Clark, Andrew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489520/
https://www.ncbi.nlm.nih.gov/pubmed/28659609
http://dx.doi.org/10.1038/s41598-017-04100-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489520/
https://www.ncbi.nlm.nih.gov/pubmed/28659609
http://dx.doi.org/10.1038/s41598-017-04100-1

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