IDO and galectin-3 hamper the ex vivo generation of clinical grade tumor-specific T cells for adoptive cell therapy in metastatic melanoma

Adoptive T cell transfer (ACT) with ex vivo-expanded tumor-reactive T cells proved to be successful for the treatment of metastatic melanoma patients. Mixed lymphocyte tumor cell cultures (MLTC) can be used to generate tumor-specific T cells for ACT; however, in a number of cases tumor-reactive T ce...

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Detalles Bibliográficos
Autores principales: Melief, Sara M., Visser, Marten, van der Burg, Sjoerd H., Verdegaal, Els M. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489610/
https://www.ncbi.nlm.nih.gov/pubmed/28401257
http://dx.doi.org/10.1007/s00262-017-1995-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489610/
https://www.ncbi.nlm.nih.gov/pubmed/28401257
http://dx.doi.org/10.1007/s00262-017-1995-x

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